![]() ![]() Set the stage for the discovery that peptide trophic factors promote the survival of a wide variety of cell types in vitroĪnd in vivo ( Levi-Montalcini 1987). The purification in the 1950s of the nerve growth factor (NGF), which promotes the survival of sympathetic neurons, The induction of developmental cell death is a highly regulated process and can be suppressed by a variety of extracellular It has since been established that approximately half of all neurons in the neuroaxis and >99.9% of the total number ofĬells generated during the course of a human lifetime go on to die through a process of apoptosis (for review, see Datta and Greenberg 1998 Vaux and Korsmeyer 1999). The programmed cell death that occurs as part of normal mammalian development was first observed nearly a century ago ( Collin 1906). Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA. ![]()
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